Biological Engineering Science

Active Projects:

-Mechanosesnsitive channels in lipid membrane using MDeFEM. 

The gating mechanism of mechanosensitive channels opens a window to the exploration of how different mechanical stimuli induce adaptive cellular behaviors of both the protein and the lipid, across different time and length scales. We had works done through a molecular dynamics-decorated finite element method (MDeFEM), the gating behavior of mechanosensitive channels of small conductance (MscS) in Escherichia coli (E. coli) is studied upon membrane stretch or global bending. 

Columbia Affiliations